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A novel mechanism by which plexin-mediated signaling can be regulated and explains how Sema4D can exert different biological activities through the differential association of its receptor with ErbB-2 and Met.
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By binding plexin B1 receptor it functions as an R-Ras GTPase-activating protein GAP and repels axon growth cones in both the mature central nervous system. 3 2 9 2. Multivariate analysis revealed that CD100 expression and tumor size were independent prognosticators for overall survival. Inhibition of Sema4DPlexinB1 signaling alleviates vascular dysfunction in. 3 7 6 6.
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